Our laboratory is interested in understanding the interactions between microbes and their hosts at the molecular and cellular levels, specifically in terms of the immune system. The first defense mechanism of the immune system is to recognize microbes and respond accordingly. This starts with discrimination of non-self from self. Some receptors, which are known as pattern recognition receptors (PRRs), can recognize patterns of molecules (ligands: PAMP) president in non-self. These receptors are highly regulated and controlled in terms of transcription and translation by different enzymes, proteins, and also post-translational modifications. In case of dysregulation, receptors can be activated by our own molecules and attack our body which can cause deterioration of cells and tissues and failure of organs. Therefore, we aim to understand the mechanisms of activation, regulation, and control of PRRs and also use ligands in order to activate or suppress innate immunity against cancer, pathogen-induced or autoimmune diseases. Our interdisciplinary background helps us to modify these ligands using biotechnology to elevate the magnitude of the effectiveness of therapy. Our research interests include:
1. Designing novel immunostimulant agents and vaccines using immunoengineering and nanobiotechnology against cancer and infectious diseases (Liposomal rotavirus vaccine, liposomal combinational immunostimulant agents),
2. Identification of new regulation mechanisms of pattern recognition receptors (PRRs), particularly RIG-I receptor (self vs non-self RNA amount-based mechanisms),
3. Elucidation of PRR regulation mechanisms in terms of age-specific differences,
4. Last but not least, understanding the evolutionary role of viruses in terms of innate immune system development.